2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0666S2
    DL-Aspartic acid-d3 14341-75-4 99.56%
    DL-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
    DL-Aspartic acid-d3
  • HY-W011955
    8-Cyclopentyl-1,3-dimethylxanthine 35873-49-5 99.82%
    8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) is a selective adenosine A1 receptor antagonist with Kis of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.
    8-Cyclopentyl-1,3-dimethylxanthine
  • HY-W012982
    3-Amino-2-oxazolidinone 80-65-9 ≥98.0%
    3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo. 3-Amino-2-oxazolidinone is orally active.
    3-Amino-2-oxazolidinone
  • HY-W014394
    Vanillyl butyl ether 82654-98-6 99.67%
    Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether exhibits mutually inhibitory effects on mammalian TRPV1 and TRPM8 channels. Vanillyl butyl ether shows repellency activity against Tribolium castaneum, T. confusum and L. bostrychophila. Vanillyl butyl ether acts as a mild warming agent, providing a warming sensation and enhancing blood circulation.
    Vanillyl butyl ether
  • HY-W016823
    Tyramine hydrochloride 60-19-5
    Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods.
    Tyramine hydrochloride
  • HY-W022047
    nNOS-IN-1 945762-00-5 99.53%
    nNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively.
    nNOS-IN-1
  • HY-W091734
    Methyl 4-iodo-L-phenylalaninate hydrochloride 158686-46-5
    Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease.
    Methyl 4-iodo-L-phenylalaninate hydrochloride
  • HY-W111226
    Fmoc-His(3-Me)-OH 252049-16-4 ≥98.0%
    Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel.
    Fmoc-His(3-Me)-OH
  • HY-W195048
    Tetradecyl sulfate sodium 1191-50-0 ≥98.0%
    Tetradecyl sulfate sodium, a detergent sclerosant, is widely used to research for esophageal varices and varicose veins.
    Tetradecyl sulfate sodium
  • HY-N0830S10
    Palmitic acid-13C2 86683-25-2 99.54%
    Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
    Palmitic acid-13C2
  • HY-12184
    ONO-AE 248 211230-67-0 98.27%
    ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels.
    ONO-AE 248
  • HY-12749
    Midodrine 42794-76-3 99.67%
    Midodrine is an α1-receptor agonist, for the treatment of dysautonomia and orthostatic hypotension.
    Midodrine
  • HY-15195
    Avosentan 290815-26-8 98.15%
    Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.
    Avosentan
  • HY-15949
    Kif15-IN-2 672926-33-9 98.64%
    Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.
    Kif15-IN-2
  • HY-76144
    4-Aminobenzothioamide 4714-67-4 98.69%
    3-Aminobenzothioamide is a small H2S donor. 3-Aminobenzothioamide has the potential for the research of myocardial ischemia-reperfusion injury.
    4-Aminobenzothioamide
  • HY-B2141
    Bendazol 621-72-7
    Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats.
    Bendazol
  • HY-N0856
    Alisol C 23-acetate 26575-93-9 99.86%
    Alisol C 23-acetate, a natural product extracted from Alisma orinentale, can significantly and strongly inhibit DTH response after oral administration.
    Alisol C 23-acetate
  • HY-N8248
    Eleutherin 478-36-4 99.22%
    Eleutherin is a type of naphthoquinone derivative with the protective effect against the injury ofhuman umbilical vein endothelial cells (HUVECs), which can be isolated from the edible bulbs of Eleutherine americana (Hong-Cong).
    Eleutherin
  • HY-103136
    R-96544 167144-80-1 ≥99.5%
    R-96544 is an orally active 5-HT2A receptor antagonist. R-96544 can inhibit platelet aggregation in vitro.
    R-96544
  • HY-107398
    1-(2,3-Dichlorophenyl)ethanamine hydrochloride 39959-66-5 99.93%
    1-(2,3-Dichlorophenyl)ethanamine hydrochloride is a phenylethanolamine N-methyltransferase (PNMT) inhibitor. 1-(2,3-Dichlorophenyl)ethanamine hydrochloride effectively reduces blood pressure of spontaneously hypertensive. 1-(2,3-Dichlorophenyl)ethanamine hydrochloride can be used for the research of blood pressure.
    1-(2,3-Dichlorophenyl)ethanamine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity